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Pancreatic Cancer Clinical Trials
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Pancreatic Adenocarcinoma (MORPHEUS-PDAC)

Overview

A Phase 1b/2 randomized, open-label trial to evaluate the safety, tolerability, PK, and preliminary antitumor activity of immunotherapy-based treatment combinations in participants with metastatic pancreatic ductal adenocarcinoma. Participants will be assigned to one of several treatment arms, including etrumadenant + nab-paclitaxel + gemcitabine + atezolizumab.

Key Eligibility Criteria

  • Histologically or cytologically confirmed metastatic pancreatic ductal adenocarcinoma
  • No prior systemic treatment for pancreatic ductal adenocarcinoma

Morpheus-PDAC Clinical Trial Locations

clinicaltrials.gov

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Pancreatic Adenocarcinoma (ARC-8)

Overview

A Phase 1 open-label, dose-escalation trial to evaluate the safety, tolerability, PD, PK, and clinical activity of AB680 in combination with zimberelimab, nab-paclitaxel and gemcitabine in participants with advanced pancreatic cancer.

Key Eligibility Criteria

  • Histologically or cytologically confirmed metastatic pancreatic adenocarcinoma
  • Naive to any prior treatment, including chemotherapy, biological therapy, or targeted therapy for metastatic disease
    • Prior adjuvant therapy (including chemotherapy and/or radiotherapy) for pancreatic adenocarcinoma is permitted if neoadjuvant or adjuvant therapy was completed at least 6 months prior to trial enrollment. Prior adjuvant therapy may include nab-paclitaxel or gemcitabine
    • Participants initially diagnosed with locally advanced pancreatic cancer who have undergone chemotherapy then resection and had no evidence of disease are eligible if relapse of metastatic disease has occurred and if the last dose of chemotherapy was received more than 6 months before trial entry

ARC-8 Clinical Trial Locations

clinicaltrials.gov

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