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Domvanalimab

DOMVANALIMAB (AB154): A MONOCLONAL ANTIBODY THAT BINDS TO TIGIT, BLOCKING TUMOR IMMUNOSUPPRESSION AND INCREASING IMMUNE ACTIVITY

TIGIT-mediated signaling is known to suppress an array of anti-cancer immune cells and has been associated with poor prognosis in a variety of tumor types.

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Domvanalimab is designed to promote sustained immune activation and tumor clearance in combination with proven immunotherapy strategies. Domvanalimab blocks TIGIT with sub-nanomolar affinity, and in a Phase 1 trial, demonstrated complete receptor coverage on all TIGIT-expressing peripheral leukocytes.

Domvanalimab exhibits a favorable safety profile and is now in Phase 2 development for the treatment of first-line metastatic non-small cell lung cancer in combination with zimberelimab (anti-PD-1) and etrumadenant (a dual A2a/A2b adenosine receptor antagonist).

DOMVANALIMAB CLINICAL TRIALS

Non-small cell lung cancer, PD-L1 positive (ARC-7)

A Phase 2 trial to evaluate the safety and efficacy of zimberelimab monotherapy, domvanalimab + zimberelimab, and domvanalimab + zimberelimab + etrumadenant in front-line non-small cell lung cancer.

Multiple Cancer Types (domvanalimab + Zimberelimab)

A Phase 1b trial to evaluate the safety, tolerability, PK, PD, and clinical activity of domvanalimab ± zimberelimab in participants with advanced solid malignancies.