cells

ANTI-PD-1
ZIMBERELIMAB

ZIMBERELIMAB

A monoclonal antibody that binds PD-1, restoring the antitumor activity of T cells

Zimberelimab was in-licensed by Arcus to enable the development of precision combination regimens with full line-of-sight to the commercialization of innovative therapies for all patients who may benefit.

The most advanced study with zimberelimab is in Phase 2 development for the treatment of first-line metastatic non-small cell lung cancer, evaluating zimberelimab in combination with domvanalimab, an anti-TIGIT monoclonal antibody, and etrumadenant, the first-and-only dual A2a/A2b adenosine receptor antagonist in the clinic.

Zimberelimab is also being evaluated as monotherapy in a tumor agnostic, biomarker-selected Phase 1b trial for cancers with no approved anti-PD-1 treatment options.

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