ANTI-CD39 – AB598

CD39 is a key enzyme in the tumor microenvironment that degrades adenosine triphosphate (ATP). ATP has an important function as an immune-activating danger signal against cancer cells. Inhibiting CD39 may increase the amount of ATP in the tumor microenvironment, which could lead to enhanced anti-tumor immune response.

AB598 is an investigational monoclonal antibody that blocks CD39. By blocking CD39, AB598 is designed to preserve ATP in the tumor microenvironment, which boosts the ability of immune cells to target cancer cells.